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Quetiapine augmentation for depression: dosing pattern in routine practice

Pae, Chi-Una,b; Wang, Sheng-Mina; Han, Changsuc; Lee, Soo-Junga; Patkar, Ashwin A.b; Masand, Prakash S.d

International Clinical Psychopharmacology: January 2015 - Volume 30 - Issue 1 - p 54–58
doi: 10.1097/YIC.0000000000000055
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This study investigated the dosing patterns of quetiapine augmentation (QA) for major depressive disorder (MDD) in routine practice. Between 1 January 2009 and 31 May 2013, patients with a diagnosis of MDD who were receiving QA in conjunction with an ongoing antidepressant were recruited into this study. The electronic medical records and clinical data for a total of 977 patients were reviewed up to a year. Almost half the patients maintained QA treatment for more than 3 months. The mean duration of QA was ∼6 months, and the mean initial and maintenance doses were 23.6 and 40.7 mg/day, respectively (range=12.5–400 mg/day). The most frequent adverse events observed were somnolence, followed by dry mouth and lethargy. Our results indicate that the actual doses of QA for MDD in routine practice should be lower than the doses used in placebo-controlled clinical trials and those recommended by a regulatory agency. Adequately powered and well-controlled prospective studies are needed to better understand the exact role of low doses of QA in the treatment of MDD, particularly in routine practice.

aDepartment of Psychiatry, College of Medicine, The Catholic University of Korea

bDepartment of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, North Carolina

cDepartment of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea

dGlobal Medical Education, New York, New York, USA

Correspondence to Chi-Un Pae, MD, PhD, Department of Psychiatry, Bucheon St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Sosa-Ro 327, Wonmi-gu, Bucheon-si 420717, Gyeonggi-do, Republic of Korea Tel: +82 32 340 7067; fax: +82 32 340 2544; e-mail: pae@catholic.ac.kr

Received August 4, 2014

Accepted October 6, 2014

© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins