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Long-term efficacy of risperidone long-acting injectable in bipolar disorder with psychotic features: a prospective study of 3-year outcomes

Malempati, Rao Narasimhaa,b; Bond, David J.c; Kunz, Mauricioc; Malemati, Chaitanyab; Cheng, Amyb; Yatham, Lakshmi N.c

International Clinical Psychopharmacology: May 2011 - Volume 26 - Issue 3 - p 146–150
doi: 10.1097/YIC.0b013e328343ba60
Original Articles

Bipolar disorder (BD) with psychotic features is a difficult-to-treat form of the illness that is associated with a poor prognosis. We hypothesized that treatment with adjunctive risperidone long-acting injectable (RLAI) is well-tolerated and efficacious in treating patients with psychotic BD. Ten patients with BDI or BDII with psychotic features who were refractory to earlier treatments were prescribed adjunctive open-label RLAI 25–62.5 mg q twice weekly. The patients were followed prospectively for 3 years. The severity of mood and psychotic symptoms was measured using clinical rating scales, and information regarding relapses, hospitalizations, extra-pyramidal symptom, weight gain, and other side effects was also gathered. Young Mania Rating Scale scores, Montgomery Asberg Depression Rating Scale scores, psychosis rating scale scores, and the numbers of mood episodes and hospitalizations were reduced during 3 years of RLAI therapy compared with an equivalent pretreatment period. Only three patients experienced relapses with psychotic symptoms. Functional outcomes were also improved, with substantial numbers of previously disabled patients able to return to gainful employment and independent living. RLAI was associated with minimal extra-pyramidal symptom, modest weight gain, and few other side effects. Adjunctive RLAI can be considered as a treatment option in patients with psychotic BD.

aHotel-Dieu Grace Hospital, Windsor

bDepartment of Psychiatry, University of Western Ontario, London, Ontario

cDepartment of Psychiatry, Mood Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada

Correspondence to Lakshmi N. Yatham, MBBS, FRCPC, MRCPsych (UK), Professor of Psychiatry and Associate Head, Research and International Affairs, Mood Disorders Centre, Department of Psychiatry, University of British Columbia, Room 2C7-2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada Tel: +1 604 822 7325; fax: +1 604 822 7922; e-mail:

Received July 20, 2010

Accepted December 14, 2010

© 2011 Lippincott Williams & Wilkins, Inc.