CASE REPORTSAripiprazole in the management of post-traumatic stress disorder symptoms in returning Global War on Terrorism veteransLambert, Michael TedfordAuthor Information Department of Psychiatry, University of Texas South-Western Medical School at Dallas (UTSWMS) and North Texas Veterans Health Care System, Dallas–Fort Worth, Texas, USA Correspondence and requests for reprints to Michael T. Lambert, Department of Psychiatry, UTSWMS, Fort Worth VA Mental Health Clinic, Fort Worth Outpatient Mental Health Clinic, 6000 Western Place, Suite 300, Fort Worth, TX 76104, USA Tel: +1 817 5702230; fax: +1 817 5702231; e-mail: [email protected] Received 22 August 2005; accepted 22 September 2005 International Clinical Psychopharmacology: May 2006 - Volume 21 - Issue 3 - p 185-187 doi: 10.1097/01.yic.0000185021.48279.00 Buy Metrics Abstract The present study illustrates the potential use of aripiprazole as part of the management of post-traumatic stress disorder (PTSD) in returning Global War on Terrorism (GWOT) veterans. Five consecutive cases of GWOT combat-related PTSD, managed in part with the atypical antipsychotic medication aripiprazole, are presented and discussed. In four of the five cases reported, the medication was well-tolerated and was effective in the management of sleep disturbances, such as nightmares and agitated behaviours during sleep, and was also helpful in the management of hyper-arousal. In one case, the veteran experienced a paradoxical excitation response to the medication. Aripiprazole, in conjunction with other medications or psychotherapeutic interventions, should be studied further for its potential role in the management of PTSD. © 2006 Lippincott Williams & Wilkins, Inc.