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Monotherapy treatment of paruresis with gabapentin

Kaufman, Kenneth R.

International Clinical Psychopharmacology: January 2005 - Volume 20 - Issue 1 - p 53-55
CASE REPORTS
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Paruresis, the difficulty or inability to urinate in the presence of others, is a highly prevalent (7–32%) social anxiety subtype that is both chronic and pervasive. Paruresis negatively impacts quality of life. Treatment strategies have focused on psychological interventions. To date, standard social anxiety pharmacotherapies utilized in the treatment of paruresis have shown minimal efficacy. A PUBMED search revealed no references to paruresis treatment with selective serotonin reuptake inhibitors or gabapentin. This case report presents the first instance of successful monotherapy treatment of paruresis with gabapentin. The patient's relative medicine noncompliance resulted in an on–off–on treatment design with a dose-dependent response. Efficacy persisted throughout a 7-month treatment course. Gabapentin should be studied further for its potential use in the treatment of paruresis.

Departments of Psychiatry and Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

Correspondence and requests for reprints to Kenneth R. Kaufman, Departments of Psychiatry and Neurology, UMDNJ-Robert Wood Johnson Medical School, 125 Paterson Street, Suite ♯2200, New Brunswick, NJ 08901, USA

Tel: +1 732 235 7647; fax: +1 609 275 5464;

e-mail: kaufmakr@umdnj.edu

Received 31 August 2004 Accepted 19 October 2004

© 2005 Lippincott Williams & Wilkins, Inc.