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Risperidone plus lithium versus risperidone plus valproate in acute and continuation treatment of mania

Yatham, Lakshmi N.a; Binder, Carinb; Kusumakar, Vivekc; Riccardelli, Rosannab

International Clinical Psychopharmacology: March 2004 - Volume 19 - Issue 2 - p 103-109
Original Articles

This exploratory analysis was performed to compare the efficacy and tolerability of risperidone when added to two different mood stabilizers (lithium or valproate) for mania in bipolar disorder. Patients receiving lithium or valproate at baseline were drawn from the database of a 12-week, open-label risperidone study. The primary efficacy measure was the Young Mania Rating Scale (YMRS). Other assessments included the Hamilton Rating Scale for Depression (HAM-D), Clinical Global Impression (CGI) of improvement, and safety measures. The analysis included 33 patients on lithium plus risperidone and 46 patients on valproate plus risperidone. Both subgroups had comparable baseline YMRS scores (lithium 28.2, valproate 28.7) and both had significant reductions in score by week 1 (P<0.0001). Comparable reductions in score continued for both subgroups until the end of the study (YMRS scores at week 12: lithium 4.6 and valproate 6.7). There were no significant differences in response rates (≥50% improvement on YMRS) or remission rates (YMRS score ≤8) between the two subgroups. At week 12, 88% of the lithium plus risperidone patients and 80% of the valproate plus risperidone patients were in remission. Similarly, HAM-D scores were significantly and comparably reduced in both subgroups, and improvement in CGI was the same. There was no difference between subgroups in the incidence of adverse events or weight gain. These data suggest that risperidone can be safely combined with either lithium or valproate, and that the efficacy is similar regardless of the mood stabilizer used.

aUniversity of British Columbia, Vancouver, British Columbia

bJanssen-Ortho Inc., Toronto

cJanssen Research Foundation, Titusville, Canada

Correspondence and requests for reprints to Lakshmi N. Yatham, Director, Mood Disorders Clinical Research Unit, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1 Canada

Tel: +1 604 822 7325; fax: +1 604 822 7922;


Received 2 May 2003 Accepted 2 December 2003

© 2004 Lippincott Williams & Wilkins, Inc.