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Optimal dose of risperidone and olanzapine for patients with schizophrenia in Taiwan

Liu, Chia-Yiha; Chiu, Nan-Yingb; Wu, Ching-Kuanc; Yuan, Lo-Mingd; Hsiao, Mei-Chuna; Liao, Oscare

International Clinical Psychopharmacology: January 2003 - Volume 18 - Issue 1 - p 49-51
Short Communication

Risperidone and olanzapine-administration data were collected for schizophrenia patients treated at four Taiwanese medical centres. Only stable patients maintained on a medication at a dose that had remained unchanged for more than 1 month were included in the analysis. Of the 268 cases, 175 were treated with risperidone and 93 with olanzapine at mean daily doses of 3.56 ± 1.54 mg and 12.21 ± 4.99 mg, respectively. The majority of the risperidone-treated patients (73.2%) received 2–4 mg per day, with another 19.0% receiving 5–6 mg. A daily dose of 10–20 mg was received by 82.9% of the olanzapine group. Although the mean daily doses for both drugs were slightly higher for inpatients than outpatients, statistical significance was not achieved. Further, no gender or age-group dose differences were demonstrated for either drug.

aDepartment of Psychiatry, Chang Gung Memorial Hospital, Linkou and Chang Gung University, Taoyuan

bDepartment of Psychiatry, Chang-Hua Christian Hospital, Chang-Hua

cDepartment of Psychiatry, Chang Gung Memorial Hospital-Kaohsiumg, Kaohsiumg

dDepartment of Psychiatry, Wei Gong Memorial Hospital, Miaoli

eJanssen-Cilag, Taiwan

Correspondence and requests for reprints to Dr Chia-Yih Liu, Department of Psychiatry, Chang Gung Memorial Hospital (CGMH), 5 Fu-Shin Street, Kuei-san, Tao-yuan 333, Taiwan.

Fax: +886 3 3280267; e-mail:

Received 1 July 2002 Accepted 29 October 2002

© 2003 Lippincott Williams & Wilkins, Inc.