Research Reports: PDF OnlyBerk M; Ichim, L; Brook, SInternational Clinical Psychopharmacology: November 1999 - p 339-343 Buy Abstract Neuroleptics are of established efficacy in mania. Controlled data on the use of olanzapine in mania is however, absent. In this study, 30 patients meeting DSM-IV criteria for mania were randomly allocated to receive either olanzapine or lithium in a 4 week double-blind randomized controlled design. There were no significant outcome differences between the two groups on any of the primary outcome measures, the Brief Psychiatric Rating Scale (lithium 28.2; olanzapine 28.0; P=0.44); Clinical Global Impression (CGI) improvement scale (lithium 2.75, olanzapine 2.36; P=0.163) or the Mania Scale (lithium 13.2, olanzapine 10.2; P=0.315). Olanzapine was however, significantly superior to lithium on the CGI-severity scale at week 4 (lithium 2.83, olanzapine 2.29; P=0.025). Olanzapine did not differ from lithium in terms of treatment emergent extrapyramidal side-effects as measured by the Simpson-Angus Scale. Olanzapine appears to be at least as effective as lithium in the treatment Of mania © 1999 Lippincott Williams & Wilkins, Inc.