In Brief:
This case illustrates the multi-systemic manifestations of parvovirus infection while highlighting edema as a unique finding. Krishnan et al. discuss the potential mechanisms by which parvovirus infection could lead to edema, including myocarditis, glomurulonephritis, and a capillary-leak like syndrome. Clinicians should be aware of this unique manifestation and include parvovirus infection in the differential for unexplained generalized edema.