Case ReportsA Case of Kaposi Sarcoma–Related Immune Reconstitution Inflammatory SyndromeWalde, Charles MS4*; Merritt, Karissa DO†; Trotman, Robin DO, FIDSA‡Author Information From the *University of Missouri, Columbia †Cox Family Medicine ‡CoxHealth Infectious Diseases Specialty Clinic, CoxHealth, Springfield, MO. Correspondence to: Charles Walde, MS4, 1325 E University Street, Springfield, MO 65804. E-mail: firstname.lastname@example.org; or Karissa Merritt, DO, Cox Family Medicine, 1423 N Jefferson St, Springfield, MO 65802. E-mail: email@example.com. The authors have no funding or conflicts of interest to disclose. Online date: November 15, 2019 Infectious Diseases in Clinical Practice: January 2020 - Volume 28 - Issue 1 - p 34-36 doi: 10.1097/IPC.0000000000000790 Buy Metrics AbstractIn Brief Immune reconstitution inflammatory syndrome is a complication of antiretroviral therapy in advanced human immunodeficiency virus infection and acquired immunodeficiency syndrome. We describe the uncommon presentation of undiagnosed Kaposi sarcoma after antiretroviral therapy initiation. Kaposi sarcoma can manifest after initiation of antiretroviral therapy and may necessitate cytotoxic chemotherapy. Immune reconstitution infl ammatory syndrome is a complication of antiretroviral therapy (ART) in advanced human immunodefi ciency virus infection and acquired immunodefi ciency syndrome. The authors describe the rare presentation of undiagnosed, Kaposi sarcoma after ART initiation. Kaposi sarcoma can manifest after initiation of ART and may necessitate cytotoxic chemotherapy Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.