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QUINOLONES AND FALSE-POSITIVE URINE SCREENING FOR OPIATES BY IMMUNOASSAY TECHNOLOGY

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Infectious Diseases in Clinical Practice: January 2002 - Volume 11 - Issue 1 - p 35
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QUINOLONES AND FALSE-POSITIVE URINE SCREENING FOR OPIATES BY IMMUNOASSAY TECHNOLOGY

[Baden LR et al. JAMA 2001;286:3115]:

The authors studied the effect of 13 quinolones in 5 commercial opiate screening assays. The results showed that nine caused assay results above the threshold for a positive result in at least one assay. The authors conclude that cross-reactivity of quinolones with the immunoassay for opiates requires scrutiny when evaluating these results in the context of screening for substance abuse.

Comment.

This is obviously a practical issue in an era when there are many patients taking fluoroquinolones and there is extensive screening for drug abuse in the context of athletic participation, job retention, and employment recruitment.

© 2002 Lippincott Williams & Wilkins, Inc.