Secondary Logo

Journal Logo

SPECIAL ARTICLES: News Excerpts

COMPARISON OF NEW TOPICAL TREATMENTS FOR HERPES LABIALIS: EFFICACY OF PENCICLOVIR CREAM, ACYCLOVIR CREAM, AND N-DOCOSANOL CREAM AGAINST EXPERIMENTAL CUTANEOUS HERPES SIMPLEX VIRUS TYPE 1 INFECTION

Author Information
Infectious Diseases in Clinical Practice: January 2002 - Volume 11 - Issue 1 - p 35
  • Free

COMPARISON OF NEW TOPICAL TREATMENTS FOR HERPES LABIALIS: EFFICACY OF PENCICLOVIR CREAM, ACYCLOVIR CREAM, AND N-DOCOSANOL CREAM AGAINST EXPERIMENTAL CUTANEOUS HERPES SIMPLEX VIRUS TYPE 1 INFECTION

McKeough MB, Spruance SL Arch Derm 2001;137:1153]:

The authors compared three topical treatments (penciclovir cream, acyclovir cream, and docosanol cream) in a guinea pig model of HSV infection. Penciclovir was superior to acyclovir cream in reducing the number of lesions (19% vs. 0%), area involved (38% vs. 21%) and virus titer (88% vs. 75%). The n-docosanol cream failed to show any differences compared to controls. The authors conclude that penciclovir cream is superior to the other two topical preparations in this animal model and presumably in people as well.

© 2002 Lippincott Williams & Wilkins, Inc.