Review ArticleHow Are Older Adults Different Than Other Adults for Infections?Scott, Donald∗; Bond, Mary∗; Manning, T. Hunter∗; Lin-Greenberg, Alan MD†; Rosenthal, Ken S. PhD∗,‡ Author Information From the ∗AU/UGA Medical Partnership, Athens, GA †The Southern Nevada Health District, Las Vegas, NV ‡NEOMED, Rootstown, OH. Correspondence to: Ken S. Rosenthal, PhD, Russell Hall Rm 157, 1425 Prince Ave, Athens, GA 30602. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. D.S. and M.B. provided equivalent authorship of this article. Infectious Diseases in Clinical Practice 31(1):e1197, January 2023. | DOI: 10.1097/IPC.0000000000001197 Buy Metrics Abstract The presentation of an infectious disease in an older adult, especially in a frail older adult or in the oldest old (≥80 years), may differ from other adults. In addition to differences in immune response, there are significant differences in anatomy, physiology, biochemistry, mental status, living conditions, and behavior that affect susceptibility, course of disease, presentation, severity, and treatment. This is the second of a series of reviews that examine differences in disease presentation for different demographics. This short review will look at some of the parameters that ask, “How are older adults different than other adults for infections?” Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.