Review ArticleCryptococcal Laryngitis Report of a Case and Comprehensive Review of the LiteratureMyer, Ashley B. BA∗; File, Thomas M. Jr MD, MS†; Kellermier, Harry C. MD‡; Myers, Joseph P. MD† Author Information From the ∗Northeast Ohio Medical University, Rootstown †Infectious Disease Division, Department of Medicine ‡Department of Pathology, Summa Health, Akron, OH. Correspondence to: Joseph P. Myers, MD, Department of Medicine, Summa Health/Akron City Hospital, 55 Arch St, Suite 1A, Akron, OH 44304. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice 31(1):e1183, January 2023. | DOI: 10.1097/IPC.0000000000001183 Buy Metrics Abstract Introduction Cryptococcus neoformans infects immunocompromised and occasionally noncompromised individuals. Cryptococcus neoformans can cause primary localized laryngitis often associated with inhaled corticosteroid therapy. We report a woman with cryptococcal laryngitis who presented with hoarseness and resultant difficulty singing in her church choir. Case Description A 75-year-old asthmatic woman had a 1-year history of hoarseness and difficulty singing in her church choir. The medications are as follows: inhaled mometasone/formoterol, inhaled montelukast, and pantoprazole. She cleans her gutters without mask protection. The examination showed only hoarseness of voice. Strobovideolaryngoscopy revealed nodule on right true vocal cord. Biopsy revealed budding yeasts with a mucicarmine-positive capsule compatible with Cryptococcus species. She was treated with oral fluconazole 400 mg daily and her voice dramatically improved at 6-week follow-up. Discussion Laryngeal cryptococcosis is a localized form of cryptococcal disease. It was first reported in 1975. This is the 33rd reported case of cryptococcal laryngitis. We herein review the literature. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.