REVIEWARTICLEAdenovirus Enterocolitis in Hematopoietic Stem Cell Transplant Patients A Report of 2 Cases and Literature ReviewLeMay, Daniel BS∗; Handley, Guy MD†; Baluch, Aliyah MD‡; Greene, John N. MD§ Author Information From the ∗University of South Florida Morsani College of Medicine †Infectious Disease Department, USF Health ‡Infectious Disease Department, Moffitt Cancer Center §Moffitt Cancer Center and Research Institute, Tampa, FL. Correspondence to: John N. Greene, MD, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3, Tampa, FL 33612-9497. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice 31(1):e1203, January 2023. | DOI: 10.1097/IPC.0000000000001203 Buy Metrics Abstract Adenovirus is a major pathogen implicated in infections among the immunocompromised, particularly patients who have undergone hematopoietic stem cell transplantation (HSCT). These infections may be life-threatening in patients with altered immune status, and recognition of the presence of adenovirus is crucial for patient management. Adenoviruses can infect many organ systems common to other pathogens and may even present similarly to noninfectious causes of disease in immunosuppressed groups, such as graft-versus-host disease. Understanding the prevalence, risk factors, presentations, diagnostic methods, and treatment options for adenovirus should guide clinicians toward recognition and, when necessary, treatment. In this article, we will review the literature on adenovirus infections with an emphasis on gastrointestinal infections in the setting of HSCT, as well as present 2 cases seen at our cancer center. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.