Review ArticlesA Case of Streptococcus intermedius Abscess Within a Malignant Neck Mass and Review of the LiteratureCummins, Kaelyn C. AB∗; Lin, Doris MD, MS†Author Information From the ∗School of Medicine †Department of Medicine, Baylor College of Medicine, Houston, TX. Correspondence to: Doris Lin, MD, MS, Department of Medicine, Baylor College of Medicine 1504 Taub Loop, 2PA 71009 Houston, TX 77030. E-mail: [email protected]. The authors have no conflicts of interest to disclose. Infectious Diseases in Clinical Practice: September 2021 - Volume 29 - Issue 5 - p e267-e271 doi: 10.1097/IPC.0000000000001007 Buy Metrics Abstract Streptococcus intermedius is an organism found commensally in various mucosal sites. Over the past couple decades, it has been recognized as a cause of severe pyogenic infections in sites including the brain, liver, lung, head and neck. Here, we describe an uncommon case of S. intermedius infection in a patient with tonsillar squamous cell carcinoma and a metastatic neck mass with overlying postradiation skin changes. We also review the literature on this pathogen in cancer patients because it remains understudied despite its pathogenicity. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.