Case ReportsWound Infection With Enterococcus hirae Associated With Cat LitterBlaseg, Nathan A. BS∗; Hoover, Susan E. MD∗,†Author Information From the ∗Department of Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, SD †Division of Infectious Diseases, Sanford Health, Sioux Falls, SD. Correspondence to: Nathan A. Blaseg, BS, 1400 W 22nd St, Sioux Falls, SD 57105. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice: July 2021 - Volume 29 - Issue 4 - p e242-e243 doi: 10.1097/IPC.0000000000000959 Buy Metrics Abstract We report a case of wound infection caused by Enterococcus hirae in a 60-year-old woman with poorly controlled diabetes mellitus type II. She initially reported to the hospital because of chest pain and fatigue. During her hospital admission, an erythematous wound, measuring 1.5 cm in diameter, was discovered along the medial aspect of her right foot. Debridement of the wound revealed small pebbles, which the patient identified as cat litter. Wound cultures identified E. hirae, a known feline commensal organism and potential pathogen. Her wound was successfully treated with an inpatient course of intravenous ceftriaxone and vancomycin followed by an outpatient course of oral amoxicillin. This represents the first instance of potential transmission of E. hirae from cat to human, as well as the third documented case of E. hirae wound infection and the first in North America. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.