Immunology/Microbiology for IDWhy Is a Child Not a Miniadult for Infections?Chappell, M. Tresa MD∗; Kelly, Carrie MD∗; Rosenthal, Ken S. PhD∗,†Author Information From the ∗AU/UGA Medical Partnership, Athens, GA †NEOMED, Rootstown, OH. Correspondence to: Ken S. Rosenthal, PhD, Russell Hall, Rm 157, 1425 Prince Ave, Athens, GA 30602. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. M.T.C. and C.K. provided equivalent authorship of this manuscript. Infectious Diseases in Clinical Practice: May 2021 - Volume 29 - Issue 3 - p e169-e173 doi: 10.1097/IPC.0000000000001012 Buy Metrics Abstract The presentation of an infectious disease in a child is likely to differ from an adult and will differ at different ages of the child. In addition to differences in immune response, there are significant differences in anatomy, physiology, metabolism, and behavior that affect susceptibility, course of disease, severity, and treatment. This is the first of a series of reviews that examine differences in disease presentation for different demographics. This short review will look at some of the parameters that ask, “Why is a child not a miniadult for infections?” Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.