Case ReportsProlonged Detection of SARS-CoV-2 in a Patient With the Development of New Clinical SymptomsAwoniyi, Amaka MD∗; Rohm, Zachery MD†; Paranjape, Neha MD, MPH‡; Arinze, Folasade MD, MPH∗Author Information From the ∗Department of Internal Medicine †Department of Neurology ‡Division of Infectious Diseases, Wellstar Health System, Marietta, GA. Correspondence to: Folasade Arinze, MD, MPH, Department of Internal Medicine, Wellstar Kennestone Regional Medical Center, 677 Church St, Marietta, GA 30060-1101. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice: March 2021 - Volume 29 - Issue 2 - p e105-e108 doi: 10.1097/IPC.0000000000000960 Buy Metrics Abstract We present a case of a 65-year-old woman with a persistently positive nasopharyngeal swab for severe acute respiratory syndrome coronavirus 2 PCR who developed new complications of coronavirus disease 2019 (COVID-19) 63 days from illness onset. She presented with intermittent fevers, fluctuating disorientation, gait instability, diffuse corticospinal tract signs, and acute venous thromboembolism. No alternate diagnosis was identified. This case highlights the potential for prolonged SARS-CoV-2 PCR positivity and persistent multisystem complications (particularly neurological), even after several months of initial COVID-19 diagnosis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.