Case ReportsCombination of Remdesivir, Corticosteroid, and Convalescent Plasma for Severe COVID-19 in Periviable PregnancyLam, Helena MD; Lacasse, Alexandre MD, FACP, MScAuthor Information From the Department of Internal Medicine, SSM Health St. Mary's Hospital- St. Louis, Richmond Heights, MO. Correspondence to: Helena Lam, MD, Department of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, 6420 Clayton Rd, Richmond Heights, MO 63117. E-mail: [email protected]. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice: November 2020 - Volume 28 - Issue 6 - p e21-e23 doi: 10.1097/IPC.0000000000000925 Buy Metrics Abstract Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to a disease spectrum named COVID-19, including a severe form of pneumonia characterized by an intense inflammatory response similar to acute respiratory distress syndrome. Current management guidelines in pregnancy have been limited. In the setting of severe COVID-19 in pregnancy, including in the periviability period, combination multitargeted therapy should be strongly considered. We report a case of severe COVID-19 pneumonia in a periviable pregnancy treated with concurrent combination of remdesivir, corticosteroids, and convalescent plasma therapy, leading to rapid maternal pulmonary improvement. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.