Review ArticlesExtrapulmonary Manifestations of SARS-CoV-2 A Brief ReviewOsorio, María F. MD∗; Vaca, Richard G. MD†Author Information From the ∗School of Medicine, Universidad Espíritu Santo-Ecuador †School of Medicine, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador. Correspondence to: María Fernanda Osorio Pesantes, MD, School of Medicine, Universidad Espíritu Santo-Ecuador, Av. Samborondón S/N, Guayaquil 092301, Ecuador. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts of interest to disclose. Author Statement: M.F.O. and R.G.V. participated in writing the original draft, and review and editing. Infectious Diseases in Clinical Practice: July 2020 - Volume 28 - Issue 4 - p 196-199 doi: 10.1097/IPC.0000000000000877 Buy Metrics Abstract On December 30, 2019, the first reports of a group of patients with unknown etiology pneumonia appeared in Wuhan city, Hubei province, China. Taking into consideration the large amount of similar nucleotide sequences between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the past epidemic coronavirus, it will be appropriate to expect that such pathogens share the same cell line tropism and systemic pathology. Although several studies have, so far, identified the clinical characteristics of COVID-19 cases, there is very little knowledge on the extrapulmonary affection of SARS-CoV-2. In this review, we summarize reports of the main affected organs besides the pulmonary system such as the liver and kidneys, as well as the cardiovascular and nervous system. The mechanisms of lesion remain largely unclear. The approach of this investigation is to suggest multisystemic work-up in patients with SARS-CoV-2 infection, aside from its respiratory management. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.