Case ReportCytomegalovirus-Induced Hemophagocytic LymphohistiocytosisJain, Hanish MD; Tambe, Ajay MBBS; Gada, Kunal MBBS; Yadava, Sanjay MD; Eranki, Ambika MD, MPHAuthor Information From the Department of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY. Correspondence to: Hanish Jain, MD, Department of Infectious Diseases, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice: May 2020 - Volume 28 - Issue 3 - p e9-e10 doi: 10.1097/IPC.0000000000000835 Buy Metrics AbstractIn Brief Hemophagocytic lymphohistiocytosis (HLH) is a rare immunopathological syndrome, which can be fatal if not diagnosed early. It is characterized by excessive immune activation and can be observed in all age groups depending on the causes of HLH. Here, we describe a case of cytomegalovirus-induced HLH in an immunocompromised host which was diagnosed in the setting of high clinical suspicion and insufficient diagnostic information. Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic infl ammatory syndrome that can be fatal. This syndrome can sometimes occur in normal people with medical problems that can cause a strong activation of the immune system, such as infection or cancer. HLH in these settings is called secondary HLH. The authors present a case of HLH induced by cytomegalovirus. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.