Pneumatosis intestinalis (PI) is a rare, possibly life-threatening, disorder that results in the buildup of gas within the wall of the gastrointestinal tract. Chemotherapy used to treat hematologic cancer patients results in prolonged neutropenia and mucositis, which increases the risk for a wide range of infections and end-organ damage. There are a few reports of PI in the setting of neutropenia in leukemia patients. Given the potential severity of PI in immunosuppressed patients, we present 3 patients with acute leukemia and review the literature on cancer patients.
From the *Morsani College of Medicine, University of South Florida, Tampa, FL;
†Faculty of Medicine, Ain Shams University, Cairo, Egypt; and
‡Moffitt Cancer Center and Research Institute, Tampa, FL.
Correspondence to: John N. Greene, MD, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3, Tampa, FL 33612-9497. E-mail: John.Greene@moffitt.org.
The authors have no funding or conflicts of interest to disclose. None of the authors have any financial ties with an organization with a financial stake in the research conducted.