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Infectious Mononucleosis Caused by Dual Infection With Cytomegalovirus and Epstein-Barr Viruses

True or False?

Dylewski, Joe, MD*; Drummond, Kenneth John, BSc

Infectious Diseases in Clinical Practice: May 2019 - Volume 27 - Issue 3 - p 170–171
doi: 10.1097/IPC.0000000000000717
Case Reports

Mononucleosis syndromes are most commonly caused by infection with either Epstein-Barr virus or cytomegalovirus. There are differences in their clinical presentation and means of acquisition. Both viruses establish lifelong latency. They are associated with inducing some degree of immunosuppression potentially resulting in reactivation of the second “infecting” virus. There are few reports of suspected dual infections, and it is serologically difficult to prove. We wish to describe 2 cases of mononucleosis for which the serologic evidence for dual infection is presented. We also wish to review the serologic tests that help establish an acute infection with each virus.

From the *Division of Microbiology and Infectious Diseases, St Mary's Hospital; and

McGill University, Montreal, Quebec, Canada.

Correspondence to: Joe Dylewski, MD, Division of Microbiology and Infectious Diseases, St. Mary's Hospital, 3830 Lacombe, Montreal, Quebec, Canada H3T 1M5. E-mail:

The authors have no funding or conflicts of interest to disclose.

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