Infectious Mononucleosis Caused by Dual Infection With Cytomegalovirus and Epstein-Barr Viruses True or False?Dylewski, Joe, MD*; Drummond, Kenneth John, BSc†Infectious Diseases in Clinical Practice: May 2019 - Volume 27 - Issue 3 - p 170–171 doi: 10.1097/IPC.0000000000000717 Case Reports Buy Abstract Author InformationAuthors Article MetricsMetrics Mononucleosis syndromes are most commonly caused by infection with either Epstein-Barr virus or cytomegalovirus. There are differences in their clinical presentation and means of acquisition. Both viruses establish lifelong latency. They are associated with inducing some degree of immunosuppression potentially resulting in reactivation of the second “infecting” virus. There are few reports of suspected dual infections, and it is serologically difficult to prove. We wish to describe 2 cases of mononucleosis for which the serologic evidence for dual infection is presented. We also wish to review the serologic tests that help establish an acute infection with each virus. From the *Division of Microbiology and Infectious Diseases, St Mary's Hospital; and †McGill University, Montreal, Quebec, Canada. Correspondence to: Joe Dylewski, MD, Division of Microbiology and Infectious Diseases, St. Mary's Hospital, 3830 Lacombe, Montreal, Quebec, Canada H3T 1M5. E-mail: email@example.com. The authors have no funding or conflicts of interest to disclose. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.