Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Amoxicillin-Clavulanate in Tuberculosis Disease

A Case Report and Review of the Current Evidence

Wheelock, Alyse, MD*; Iliaki, Eirini, MD, MPH†‡; Turner, Marie T., MD§∥

Infectious Diseases in Clinical Practice: May 2019 - Volume 27 - Issue 3 - p 126–132
doi: 10.1097/IPC.0000000000000715
Review Articles

In the treatment of tuberculosis (TB), antibiotics for presumed bacterial pneumonia may be implicated in diagnostic delays. The same antibiotics are sometimes active against TB, the quinolones being a prominent example. We present the case of a patient with multidrug-resistant TB whose symptoms and radiologic studies improved on amoxicillin-clavulanate to treat presumed necrotizing pneumonia, leading to a complicated and prolonged diagnostic course. We then review the literature on effects of amoxicillin-clavulanate in TB disease, including both in vivo and in vitro studies that have been published to date.

From the *Boston Medical Center, Boston;

Cambridge Health Alliance, Cambridge;

Harvard Medical School;

§Lemuel Shattuck Hospital, Boston; and

Tufts Medical School, Boston, MA.

Correspondence to: Alyse Wheelock, MD, 72 E Concord St, Boston MA 02118. E-mail:

Sources of support: None.

The authors have no funding or conflicts of interest to disclose.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.