Review ArticlesAmoxicillin-Clavulanate in Tuberculosis Disease A Case Report and Review of the Current EvidenceWheelock, Alyse MD*; Iliaki, Eirini MD, MPH†‡; Turner, Marie T. MD§∥Author Information From the *Boston Medical Center, Boston; †Cambridge Health Alliance, Cambridge; ‡Harvard Medical School; §Lemuel Shattuck Hospital, Boston; and ∥Tufts Medical School, Boston, MA. Correspondence to: Alyse Wheelock, MD, 72 E Concord St, Boston MA 02118. E-mail: Alyse.firstname.lastname@example.org. Sources of support: None. The authors have no funding or conflicts of interest to disclose. Infectious Diseases in Clinical Practice: May 2019 - Volume 27 - Issue 3 - p 126-132 doi: 10.1097/IPC.0000000000000715 Buy Metrics Abstract In the treatment of tuberculosis (TB), antibiotics for presumed bacterial pneumonia may be implicated in diagnostic delays. The same antibiotics are sometimes active against TB, the quinolones being a prominent example. We present the case of a patient with multidrug-resistant TB whose symptoms and radiologic studies improved on amoxicillin-clavulanate to treat presumed necrotizing pneumonia, leading to a complicated and prolonged diagnostic course. We then review the literature on effects of amoxicillin-clavulanate in TB disease, including both in vivo and in vitro studies that have been published to date. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.