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Amoxicillin-Clavulanate in Tuberculosis Disease

A Case Report and Review of the Current Evidence

Wheelock, Alyse, MD*; Iliaki, Eirini, MD, MPH†‡; Turner, Marie T., MD§∥

Infectious Diseases in Clinical Practice: May 2019 - Volume 27 - Issue 3 - p 126–132
doi: 10.1097/IPC.0000000000000715
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In the treatment of tuberculosis (TB), antibiotics for presumed bacterial pneumonia may be implicated in diagnostic delays. The same antibiotics are sometimes active against TB, the quinolones being a prominent example. We present the case of a patient with multidrug-resistant TB whose symptoms and radiologic studies improved on amoxicillin-clavulanate to treat presumed necrotizing pneumonia, leading to a complicated and prolonged diagnostic course. We then review the literature on effects of amoxicillin-clavulanate in TB disease, including both in vivo and in vitro studies that have been published to date.

From the *Boston Medical Center, Boston;

Cambridge Health Alliance, Cambridge;

Harvard Medical School;

§Lemuel Shattuck Hospital, Boston; and

Tufts Medical School, Boston, MA.

Correspondence to: Alyse Wheelock, MD, 72 E Concord St, Boston MA 02118. E-mail: Alyse.wheelock@bmc.org.

Sources of support: None.

The authors have no funding or conflicts of interest to disclose.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.