Secondary Logo

Institutional members access full text with Ovid®

Recrudescence of Plasmodium falciparum Malaria in a Patient With Progressive Sarcoidosis

Allencherril, Joseph, MD*; Hammond, Allexa, MD; Birnbaum, Gilad, MD*; Gold, Benjamin, MD*; Allencherril, Ronan, BA; Salciccioli, Katherine, MD*; El Sahly, Hana, MD§

Infectious Diseases in Clinical Practice: March 2019 - Volume 27 - Issue 2 - p 102–104
doi: 10.1097/IPC.0000000000000693
Case Reports
Buy

Although endemic malaria has largely been eradicated in the United States, cases still occur, often as a result of travel-related exposure. Although nearly all cases of Plasmodium falciparum malaria occur within 3 months of exposure, in rare instances, symptoms manifest years after the sentinel infection because of compromise of immunity and parasite recrudescence. We describe a case of a 49-year-old woman with a history of childhood malaria and no recent travel history who presented with P. falciparum malaria in the setting of progressing pulmonary sarcoidosis. This case report highlights the role of advancing immune compromise status in malarial recrudescence. We also consider other potential avenues to explain how a patient might develop P. falciparum malaria in a nonendemic region in the absence of recent travel.

In rare instances, symptoms of malaria may manifest years after the sentinel infection, due to compromise of immunity and parasite recrudescence. The authors describe a case of a 49-year-old woman with a history of childhood malaria and no recent travel history who presented with Plasmodium falciparum malaria in the setting of progressing pulmonary sarcoidosis. This case report highlights the role of advancing immune compromise status in malarial recrudescence.

From the *Department of Medicine, Baylor College of Medicine, Houston;

Department of Medicine, University of Texas Southwestern Medical Center, Dallas;

University of Texas Medical Branch, Galveston; and

§Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX.

Correspondence to: Joseph Allencherril, MD, Department of Medicine, Baylor College of Medicine, Houston, One Baylor Plaza, Houston, TX 77030. E-mail: allenche@bcm.edu.

The authors have no funding or conflicts of interest to disclose.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.