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Slowly Evolving Brain Abscess Caused by Nocardia beijingensis in a Kidney Transplant Patient

Nasser, Roni, MD*; Korytny, Alexander, MD*; Geffen, Yuval, PhD, MHA; Andraous, Maisa, MD; Paul, Mical, MD§∥; Braun, Eyal, MD*§∥

Infectious Diseases in Clinical Practice: November 2018 - Volume 26 - Issue 6 - p 369–370
doi: 10.1097/IPC.0000000000000645
Case Reports

A 71-year-old actively working farmer was admitted because of progressive weakness of the left hand and leg starting 5 weeks before admission. He has been suffering from headaches in the last 4 years. He has undergone kidney transplantation 14 years before admission. Brain magnetic resonance imaging (MRI) revealed a right frontoparietal hypodense lesion measuring 22 × 34 × 17 mm, causing edema, suspected to represent an abscess. Reviewing 2 brain MRI scans performed 4 years 10 months before admission showed a gradually worsening pathological process in the same region. Open surgery revealed an abscess, and drainage was performed. Gram stain and culture from the pus were negative, but panbacterial polymerase chain reaction was positive for Nocardia beijingensis. The patient was treated with ceftriaxone and linezolid for 3 months followed by trimethoprim-sulfamethoxazole. Repeated MRI 2 weeks after drainage showed reduction in abscess size. Brain computed tomography 3 months later showed further improvement. The patient has never recovered and died 8 months later.

From the *Internal Medicine Wards B and H,

Clinical Microbiology Laboratory,

Radiology Department, and

§Infectious Diseases Institute, Rambam Health Care Campus; and

The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Correspondence to: Roni Nasser, MD, HaAliya, HaShniya 8, Haifa 3109601, Israel. E-mail: roni.nasser@gmail.com.

The authors have no funding or conflicts of interest to disclose.

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