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Moraxella Species Bacteremia in Cancer Patients

A Case Series and Review of the Literature

Denham, James Dustin MS*; Nanjappa, Sowmya MBBS, MD; Greene, John N. MD

Infectious Diseases in Clinical Practice: July 2018 - Volume 26 - Issue 4 - p 188–190
doi: 10.1097/IPC.0000000000000628
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Moraxella is a genus of gram-negative diplococci considered to be an important cause of upper respiratory tract disease in humans. Bacteremia caused by Moraxella species, however, remains rare and tends to occur in individuals with a compromised immune system. We reviewed all cultures positive for Moraxella species at an academic cancer hospital between the years of 2011 and 2016. We also performed a literature review of Moraxella species bacteremia in cancer patients in the decade between 2006 and 2016. At the H. Lee Moffitt Cancer Center, between 2011 and 2016, there were 41 positive cultures (from all sites) for Moraxella species. Of these 41 cultures, only 3 were positive blood cultures. Our findings indicate that bacteremia caused by Moraxella species can range in severity from fever and chills to frank sepsis. As has been noted in other publications, the source of the bacteremia is not always clinically apparent, but upper and lower respiratory sources seem to predominate. None of the patients presented in this case series died of their bacteremia. The 2 publications discovered in our literature review similarly describe 2 nonfatal cases of Moraxella osloensis bacteremia: 1 case in a patient with a recent diagnosis of acute myeloid leukemia and 1 case in a patient with an unspecified lung cancer.

Moraxella is a genus of Gram-negative diplococci that are carried in the nasopharynx of humans. The authors report a series of three cases of organisms within this genus causing bacteremia in cancer patients and review the literature regarding resistance patterns, treatment, and clinical manifestations of these organisms.

From the *University of South Florida Morsani College of Medicine;

Department of Internal Medicine and Department of Oncologic Sciences, H. Lee Moffitt Cancer Center, University of South Florida Morsani College of Medicine; and

Infectious Diseases and Hospital Epidemiologist, Moffitt Cancer Center and Research Institute, Tampa, FL.

Correspondence to: John N. Greene, MD, Infectious Diseases and Hospital Epidemiologist, Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, FOB-3, Tampa, FL 33612-9497. E-mail: john.greene@moffitt.org.

The authors have no conflicts of interest to disclose. None of the authors are affiliated with, or have financial involvement in any organization or entity with direct financial involvement in the subject matter or materials of the research discussed in this article. All authors have participated significantly in writing of this article and approve of its content. There is no material that is under the copyright of another party or appearing in another unpublished manuscript. The final manuscript has been seen and approved by all authors.

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