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Invasive Pulmonary Aspergillosis and Methicillin-Resistant Staphylococcus aureus Associated With Influenza A Infection

Ballal, Megana L., MD; Shirvanian, Shant, MD; Halai, Umme-Aiman, MD; Graber, Christopher J., MD; Betancourt, Jaime, MD

Infectious Diseases in Clinical Practice: July 2018 - Volume 26 - Issue 4 - p 234–236
doi: 10.1097/IPC.0000000000000563
Case Reports

Bacterial superinfection is a known complication of influenza infection, with Streptococcus pneumoniae and Staphylococcus aureus often being the offending pathogens. In recent decades, there has been an increased prevalence of superinfection with Aspergillus in seemingly immunocompetent hosts. We describe a fatal case of influenza complicated by simultaneous methicillin-resistant S. aureus pneumonia and invasive pulmonary aspergillosis.

Over the past few decades, there has been an increasing incidence of invasive fungal infections among relatively immunocompetent hosts. This report describes a fatal case of inf luenza complicated by simultaneous methicillin-resistant Staphylococcus aureus pneumonia and invasive pulmonary aspergillosis. The recognition of nontraditional risk factors associated with this disease is crucial to avoid delays in treatment and to reduce morbidity and mortality.

From the Pulmonary and Critical Care Section and Infectious Diseases Section, Department of Medicine, West Los Angeles Veterans Affairs Healthcare Center, Los Angeles, CA.

Correspondence to: Megana L. Ballal, MD, West Los Angeles Veterans Affairs Healthcare Center, 11301 Wilshire Blvd, Los Angeles, CA 90073. E-mail:

The authors have no funding or conflicts of interest to disclose.

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.