Acute Appendicitis in the Setting of Infectious Mononucleosis: A Case Report and Review of LiteratureAli Imtiaz, Mubdiul MD; Jaggi, Shuchie DO; Sorathia, Sufian; Dave, Vinnidhy DO; Rohant, Namit; Sperber, Steven J. MDInfectious Diseases in Clinical Practice: September 2014 - Volume 22 - Issue 5 - p 253–256 doi: 10.1097/IPC.0000000000000136 Review Article Abstract Author Information Acute appendicitis is a rare complication of infectious mononucleosis (IM) and should be considered as a possible etiology of persistent abdominal pain in a patient with IM. We present a patient with IM and an incidental computed tomography diagnosis of acute appendicitis without any clinical features of appendicitis on serial abdominal examinations. Based on a review of published literature, this may be the first reported case of simultaneous presentation of IM and acute appendicitis, where no surgical intervention was performed to treat appendicitis. Appendicitis and IM appearing simultaneously lead to a high suspicion of infiltration of lymphocytes produced during IM into the appendix. Appendicitis may be monitored medically in cases of no clinical signs of acute appendicitis in patients with IM. From the New Jersey Medical School–Rutgers, the State University of New Jersey, Hackensack University Medical Center, Hackensack, NJ. Correspondence to: Mubdiul Ali Imtiaz, MD, 67 Brookdale Gardens, Apt C, Bloomfield, NJ 07003. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts of interest to disclose. © 2014 by Lippincott Williams & Wilkins.