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Cytomegalovirus Appendicitis in Human Immunodeficiency Virus Infection

Jameson, Andrew MD; Kauffman, Carol A. MD; Cinti, Sandro K. MD; Gandhi, Tejal MD

Infectious Diseases in Clinical Practice: July 2014 - Volume 22 - Issue 4 - p 190–193
doi: 10.1097/IPC.0000000000000112
Review Articles

We report 2 cases of cytomegalovirus-associated appendicitis in patients infected with human immunodeficiency virus and review 8 additional patients with cytomegalovirus appendicitis who were identified in the English-language literature. The clinical course and acute symptoms were very similar when these patients were compared with immunocompetent patients who had appendicitis. Laboratory findings and concomitant opportunistic infections set this disease process apart in human immunodeficiency virus–infected patients. Treatment was primarily surgery with adjunctive antiviral therapy. Accurate and timely diagnosis requires a high index of suspicion on the part of clinicians.

From the Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI.

Correspondence to: Andrew Jameson, MD, Division of Infectious Diseases, Department of Internal Medicine, 1500 E. Taubman Medical Center Dr, 3119 Taubman Center, Ann Arbor, MI 48109-5378. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.