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A 31-Day-Old Infant With Late-Onset Sepsis and Complicated Pneumonia Due to Streptococcus pyogenes

Bekkam, Giridhar Janampet MBBS*†; Dumpa, Vikramaditya MD, MS*†; Tolan, Robert W. Jr MD*†‡§

Infectious Diseases in Clinical Practice: July 2014 - Volume 22 - Issue 4 - p e58–e59
doi: 10.1097/IPC.0b013e3182a0e94e
Case Reports

Group A Streptococcus (GAS) was a major cause of neonatal sepsis before the antibiotic era, but its incidence declined with the availability of antibiotics and improved perinatal infection prevention measures. It is now a rare cause of neonatal sepsis. Streptococcus pyogenes sepsis in early infancy can be associated with a variety of complications. Complicated pneumonia (pneumonia with effusion, empyema, or necrosis) has been reported in 3 bacteremic infants with early-onset sepsis. This is the first report of complicated pneumonia in late-onset sepsis due to S pyogenes.

Although an unusual cause of sepsis in the first months of life, GAS remains an important pathogen for the delivering mother and newborn infant. As this case illustrates, complications of GAS late-onset sepsis, including complicated pneumonia, can develop. This pathogen should be considered in the evaluation of the ill newborn and young infant.

From the *Department of Pediatrics, The Children’s Hospital at Saint Peter’s University Hospital, †The Children’s Hospital at Saint Peter’s University Hospital, ‡Division of Allergy, Immunology and Infectious Diseases, The Children’s Hospital at Saint Peter’s University Hospital, New Brunswick, NJ and §Drexel University College of Medicine, Philadelphia, PA.

Correspondence to: Vikramaditya Dumpa, MD, Division of Neonatology, Women and Children’s Hospital of Buffalo, 219 Bryant St, Buffalo NY 14226. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.