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Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Prosthetic Valve Endocarditis With Ceftaroline

Najjar, Sessine MD*; Biehle, Lauren PharmD; Najjar, Joe MD*; Finkel, Diana G. DO*

Infectious Diseases in Clinical Practice: March 2014 - Volume 22 - Issue 2 - p 108–109
doi: 10.1097/IPC.0b013e318287c73f
Case Reports

We report a case of methicillin-resistant Staphylococcus aureus bacteremia and proven prosthetic valve endocarditis successfully treated with ceftaroline salvage therapy after clinical failure with daptomycin. The patient, allergic to vancomycin, was treated with daptomycin as monotherapy and in combination with nafcillin and gentamicin. She was found to have recurrent bacteremia and a vegetation on her bioprosthetic mitral valve. On the third day of treatment with ceftaroline, repeat blood cultures were negative. Imaging performed after the course of ceftaroline showed resolution of the vegetation. Our case documents the safety and efficacy of ceftaroline in bacteremia and prosthetic valve endocarditis.

From the *Crossroads Medical Group, Clifton, NJ; and †Cardinal Pharmacy Solutions, Houston, TX.

Correspondence to: Diana G. Finkel, DO, Crossroads Medical Group, 975 Clifton Ave, 2nd Floor, Clifton, NJ. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.