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Ocular Syphilis in Patients Infected With Human Immunodeficiency Virus: Case Report and Review of the Literature

Yadlapati, Ajay MD*; Chang, Emery MD*; Curcio, Eric MD*; Shah, Beena MD; Yadlapati, Rena MD

Infectious Diseases in Clinical Practice: March 2014 - Volume 22 - Issue 2 - p 68–70
doi: 10.1097/IPC.0b013e3182948d6c
Review Articles

Uveitis secondary to syphilis in human immunodeficiency virus (HIV)-infected individuals is a well-documented but unusual phenomenon. We report the case of a 66-year-old man with HIV recently diagnosed with early latent syphilis coinfection who presented with an acute onset of ocular symptoms and whose condition was diagnosed as anterior uveitis. After administration of appropriate antibiotic therapy for syphilitic uveitis, his ocular symptoms resolved completely. We additionally provide a literature review on the presentation and management of syphilitic uveitis. This paper highlights the importance of considering syphilis in the differential of ocular symptoms, particularly in a patient with HIV, and also demonstrates that prompt evaluation and management are of paramount significance in an otherwise deleterious disease.

From the *Department of Internal Medicine and Pediatrics, UCLA Medical Center, David Geffen School of Medicine, Los Angeles; †Department of Infectious Disease, Anaheim Memorial Medical Center, Anaheim; and ‡Department of Internal Medicine, UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA.

Correspondence to: Ajay Yadlapati, MD, Department of Internal Medicine and Pediatrics, UCLA, 757 Westwood Blvd, Room B-711, Los Angeles, CA 90095. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.