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Carbapenem-Resistant Klebsiella pneumoniae Prosthetic Valve Endocarditis: A Feared Combination of Technology and Emerging Pathogens

Raymond, Timothy DO*; Wiesen, Jonathan MD; Rehm, Susan MD; Auron, Moises MD§

Infectious Diseases in Clinical Practice: March 2014 - Volume 22 - Issue 2 - p 113–115
doi: 10.1097/IPC.0b013e318287c881
Case Reports

Klebsiella pneumoniae is a Gram-negative bacillus with a strong presence in the health care setting. Carbapenem-resistant strains of K pneumoniae (KPC) have recently become an increasing cause of nosocomial morbidity and mortality. In an era that has witnessed the production of bacteria highly resistant to conventional antibiotics, atypical sites of infection are often caused by multidrug-resistant pathogens, further complicating treatment of infectious diseases.

Klebsiella pneumoniae is rarely a cause of endocarditis; however, in patients with KPC bacteremia, physicians should be aware of the possibility of KPC endocarditis. The presence of KPC endocarditis should prompt surgical evaluation in addition to targeted antibiotic therapy. This is, to our knowledge, the first reported case of prosthetic valve KPC endocarditis.

From the Departments of *Internal Medicine, †Pulmonary, Allergy and Critical Care, ‡Infectious Diseases, and §Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH.

Correspondence to: Timothy Raymond, DO, Department of Internal Medicine, Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195. E-mail:

All authors had access to the manuscript and clinical data and images.

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.