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Diagnostic Dilemmas in Q Fever Endocarditis

Kattan, Juan Nicolas MD,; Bhimraj, Adarsh MD

Infectious Diseases in Clinical Practice: January 2014 - Volume 22 - Issue 1 - p 55–56
doi: 10.1097/IPC.0b013e318281d8f1
Case Reports

We report a case of Q fever endocarditis, with cross-reactive serology, where serum polymerase chain reaction was useful to make the diagnosis. Although serodiagnostics are the reference standard, they have limitations. They cross-react with related bacterial species and are not useful in anatomically localizing the infection. Serum polymerase chain reaction may play a promising role in the diagnosis of Q fever, especially endocarditis. Q fever should be considered in the differential diagnosis of culture-negative endocarditis in the United States.

From the Department of Infectious Disease, Cleveland Clinic, Cleveland, OH.

Correspondence to: Juan Nicolas Kattan, 9500 Euclid Ave/G21, Cleveland, OH 44195. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2014 Wolters Kluwer Health, Inc. All rights reserved.