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Whipple’s Disease: A Case Revisited 14 Years After Diagnosis

Kattan, Juan Nicolas MD*; Rehm, Susan J. MD*; van Duin, David MD, PhD*; Pettersson, Gosta MD, PhD; Rodriguez, E. René MD; Gordon, Steven Mark MD*

Infectious Diseases in Clinical Practice: May 2013 - Volume 21 - Issue 3 - p 201–203
doi: 10.1097/IPC.0b013e31826babbf
Case Reports

Whipple’s disease is a rare disease that often remains undiagnosed for long periods because of difficulties on culture of the organism and the need for advanced polymerase chain reaction techniques. For these reasons, oftentimes it is initially treated as a rheumatologic disease based on presenting symptoms. There are increasing numbers of patients who require immunosuppressive medications, and little is known about the natural history of the disease in this population. This article is a follow-up to a previously published report on a patient with Whipple’s disease hip arthritis (Arthritis Rheum 1999;42:812–817). After a kidney transplantation, he went on to develop Whipple’s endocarditis 14 years after his initial diagnosis.

From the *Departments of Infectious Disease, †Cardiothoracic Surgery, and ‡Anatomic Pathology, Cleveland Clinic, Cleveland, OH.

Correspondence to: Juan Nicolas Kattan, MD, 9500 Euclid Ave/G21, Cleveland, OH 44195. E-mail:

Dr van Duin belongs to the speakers’ bureau for Astellas and data safety monitoring board for Pfizer. All the other authors have no funding or conflicts of interest to disclose.

© 2013 Lippincott Williams & Wilkins, Inc.