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Daptomycin-Nonsusceptible Vancomycin-Resistant Enterococcal Bacteremia: A Case Report and Review of the Literature

Pound, Melanie W. PharmD, BCPS*†; Reel, Jenna E. PharmD, BCPS*

Infectious Diseases in Clinical Practice: March 2013 - Volume 21 - Issue 2 - p 79–84
doi: 10.1097/IPC.0b013e31826b9f7a
Review Articles

Antimicrobial resistance to Enterococcus faecium has been an increasing problem in the hospital setting. This case report describes a patient with multidrug-resistant E. faecium bacteremia that was nonsusceptible to daptomycin. At this time, there are only a limited number of reports in the literature; a review of these articles, including in vitro and in vivo findings, is discussed.

This report describes a case of daptomycin non-susceptible Enterococcus faecium bacteremia. A review of the literature reveals this organism is becoming more common and can be particularly challenging to treat. This article highlights the importance of increasing antimicrobial resistance and the need for antimicrobial stewardship and the development of newer antimicrobial agents with novel mechanisms of action.

From the *New Hanover Regional Medical Center, Wilmington; and †Campbell University College of Pharmacy & Health Sciences, Buies Creek, NC.

Correspondence to: Melanie W. Pound, PharmD, BCPS, Campbell University College of Pharmacy & Health Sciences, PO Box 1090, Buies Creek, NC 27506. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2013 by Lippincott Williams & Wilkins.