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Successful Treatment of Progressive Multifocal Leukoencephalopathy With Interferon

Horn, Andreas MD*†; Greene, John N. MD, FACP‡§

Infectious Diseases in Clinical Practice: September 2012 - Volume 20 - Issue 5 - p 345–348
doi: 10.1097/IPC.0b013e318245d48f
Case Reports

Progressive multifocal leukoencephalopathy is usually a fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus with a median survival time of less than 5 months. We report about a patient that had typical clinical and radiological signs of progressive multifocal leukoencephalopathy, as well as positive in situ hybridization for JC virus of brain tissue, that was successfully treated with interferon α. The patient did largely outlive the usual prognosis of the disease, and no progress of clinical symptoms or radiological findings could be found after treatment.

From the *Department for Neurology, University Hospital, Albert-Ludwigs-Universität Freiburg, Freiburg; †Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; ‡H. Lee Moffitt Cancer Center; and §Departments of Internal Medicine and Oncological Sciences, University of South Florida College of Medicine, Tampa, FL.

Correspondence to: John N. Greene, MD, FACP, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr, FOB-3, Tampa, FL 33612-9497. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2012 Lippincott Williams & Wilkins, Inc.