Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.
From the *Department of Internal Medicine, and †Division of Hematology, Department of Internal Medicine, Johns Hopkins University School of Medicine;‡National Institutes of Health, Bethesda; §Divisions of Infectious Diseases, and ∥Pulmonary and Critical Care Medicine, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Correspondence to: Kim A. Reiss, MD, Department of Internal Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe St, Nelson Building, Room 434, Baltimore, MD 21287. E-mail: firstname.lastname@example.org.
Work was performed at Johns Hopkins University School of Medicine and at the National Institutes of Health.
The authors have no funding or conflicts of interest to disclose.