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Persistent Hiccups Due to Fixed-Dose Tenofovir and Emtricitabine: A Case Report and Review of Hiccups in Patients With Human Immunodeficiency Virus

Pawlowski, Sean W. MD; Moore, Christopher C. MD; Wispelwey, Brian MD

Infectious Diseases in Clinical Practice: September 2011 - Volume 19 - Issue 5 - p 354-356
doi: 10.1097/IPC.0b013e3181f5eab1
Case Reports

Persistent hiccups in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) are most often associated with opportunistic infections or HIV-associated illnesses. There have been no described cases of hiccups due to highly active antiretroviral medications. We report a case of persistent hiccups likely due to fixed-dose tenofovir and emtricitabine and review etiologies of persistent and intractable hiccups in patients with HIV and common gastrointestinal disturbances linked to the fixed-dose formulation.

From the Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia, Charlottesville, VA.

Correspondence to: Sean W. Pawlowski, MD, University of Virginia, 345 Crispell Dr, MR6 Bldg, Room 2711, Charlottesville, VA 22908. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2011 Lippincott Williams & Wilkins, Inc.