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Abnormal Positron Emission Tomographic Scan Due to Undiagnosed Adrenal Histoplasmosis

Gelfand, Michael S. MD*; Cleveland, Kerry O. MD*; Baskin, Reed C. MD

Infectious Diseases in Clinical Practice: September 2011 - Volume 19 - Issue 5 - p 365-366
doi: 10.1097/IPC.0b013e318209973c
Case Reports

Infection with Histoplasma capsulatum may result in clinical signs and symptoms consistent with malignancy or infection. Microbiologic and immunologic diagnostic tests for histoplasmosis may yield false-negative results and lead to additional testing for the malignancies it may mimic. We report a patient with negative initial study results for infection who was found on evaluation to have bilateral adrenomegaly and adrenal uptake on 18F-fluorodeoxyglucose positron emission tomography suggestive of a neoplastic process. On further testing, the patient was found to have adrenal histoplasmosis.

From the Divisions of *Infectious Diseases and †Hematology/Oncology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN.

Correspondence to: Kerry O. Cleveland, MD, Suite 460, 1325 Eastmoreland Ave, Memphis, TN 38104. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2011 Lippincott Williams & Wilkins, Inc.