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Newly Diagnosed White Man With HIV-Associated Lupus-Like Nephropathy

Cook, Katherine D. DO*; Stroup, Jeffrey S. PharmD, BCPS; Stephens, Johnny PharmD

Infectious Diseases in Clinical Practice: May 2011 - Volume 19 - Issue 3 - p 213-217
doi: 10.1097/IPC.0b013e3181ee6292
Case Reports

Although HIV-associated nephropathy (HIVAN) is the most common form of glomerulopathy found in HIV-infected patients, other lesions have been reported. Lupus-like glomerulonephritis is a lesion that presents with diffuse proliferative immune-complex trapping with lupus-like features instead of the usual focal segmental collapsing of the glomeruli seen in HIVAN. We present a case report of a newly diagnosed HIV-positive white man who presented with dyspnea, lower-extremity swelling, and overt proteinuria. Although initially it was presumed he had a congestive heart failure, a kidney biopsy was performed that demonstrated an HIV-associated diffuse proliferative immune-complex trapping glomerulopathy with lupus-like features. This article reviews the differences between HIVAN and lupus-like glomerulonephritis.

From the *Oklahoma State University Medical Center and †Oklahoma State University Center for Health Sciences, Tulsa, OK.

Correspondence to: Jeffrey S. Stroup, PharmD, BCPS, Oklahoma State University Center for Health Sciences, 635 West 11th St, Tulsa, OK, 74127. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2011 Lippincott Williams & Wilkins, Inc.