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Disseminated Fusarium From a Primary Gingivitis After Hematopoietic Stem Cell Transplant in a Patient With Leukemia

Bueller, Hope MD*; Tucci, Veronica JD, MD; Imam, Muhammad BS; Greene, John N. MD, FACP§; Sandin, Ramon L. MD, MS, FCAP§∥

Infectious Diseases in Clinical Practice: January 2011 - Volume 19 - Issue 1 - p 51-54
doi: 10.1097/IPC.0b013e3181e53ad1
Case Reports

Invasive fungal infections continue to plague the immunocompromised population, and Fusarium species have become an increasing threat. This species of fungus is a frequent cause of local infections, such as keratitis and onychomycosis, in the immunocompetent but can bring about locally invasive and disseminated infections in the immunocompromised. These infections are associated with a high degree of morbidity and mortality. Patients with neutropenia seem to be particularly susceptible to these manifestations of Fusarium. In invasive and disseminated disease, the primary lesion is often in the sinopulmonary tree or through a wound in the skin. We report here a unique case of primary Fusarium in the gingiva of a patient who underwent hematopoietic stem cell transplant, diagnosed with relapsed acute lymphocytic leukemia that widely disseminated and led to her demise.

From the Divisions of *Infectious Diseases and International Medicine and †Infectious Diseases and Tropical Medicine, ‡Department of Internal Medicine, §H. Lee Moffitt Cancer Center and Research Institute, and ∥Clinical Microbiology and Virology Laboratories, College of Medicine, University of South Florida, Tampa, FL.

Correspondence to: John N. Greene, MD, FACP, H. Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, 12902 Magnolia Dr, WCB-BMT, Tampa, FL 33612-9497. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2011 Lippincott Williams & Wilkins, Inc.