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The Increasing Complexity of Elderly Prescribing: Myotoxicity With the Combination of Daptomycin, Atorvastatin, and Colchicine

Erlandson, Kristine Mace MD; Castillo-Mancilla, Jose MD

Infectious Diseases in Clinical Practice: November 2010 - Volume 18 - Issue 6 - p 399-401
doi: 10.1097/IPC.0b013e3181d608fa
Case Reports

Daptomycin is generally well tolerated; however, myopathy and rhabdomyolysis have been reported during therapy. Because of the risk of myalgias, other drugs with the potential for myopathy should be used cautiously in combination with daptomycin. We report a case of myopathy due to a combination of daptomycin, colchicine, and atorvastatin.

From the Division of Infectious Diseases, University of Colorado, Denver, CO.

Correspondence to: Kristine Mace Erlandson, MD, University of Colorado- Denver, Anschutz Medical Center, 12605 E 16th Ave, Mail Stop B168, Aurora, CO 80045. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.