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Successful Tigecycline Combination Therapy for Mycobacterium abscessus Infection of a Total Hip Arthroplasty

Yinkey, Linda M. DO; Halsey, Eric S. MD; Lloyd, Bradley A. MD

Infectious Diseases in Clinical Practice: July 2010 - Volume 18 - Issue 4 - p 269-270
doi: 10.1097/IPC.0b013e3181d04a09
Case Reports

Mycobacterium abscessus is a highly antibiotic-resistant rapidly growing mycobacteria. We present the first documented case of total hip arthroplasty infection caused by Mycobacterium abscessus and our experience using tigecycline after first-line therapies failed to eradicate the patient's infection. Tigecycline is a new broad-spectrum antibiotic typically used in complicated skin and intra-abdominal infections. Our report highlights the benefits and difficulties of prolonged tigecycline use. This is the first documented curative treatment of M. abscessus infection of any type of prosthetic joint and also the first successful use of tigecycline to treat a rapidly growing mycobacteria prosthetic joint infection of any species in the literature.

From the Wright Patterson Medical Center, Wright Patterson Air Force Base,OH.

Reprints: Linda M. Yinkey, DO, 18845 Sutwik Cir, Eagle River, AK 99577. E-mail:

The authors report no conflicts of interest.

There was no support for this study.

The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Air Force, the Department of Army, the Department of Navy, the Department of Defense, or the US Government.

© 2010 Lippincott Williams & Wilkins, Inc.