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Rhinocerebral Mucormycosis Complicated by Diabetes Insipidus: A Case Report and Literature Review

Magri, Caroline Jane MD, MRCP*; Piscopo, Tonio MD, MRCP, Dip T. Med.; Farrugia, Eric MD, FRCS; Fava, Stephen MD, FRCP, MPhil, PhD, FACP, FEFIM*

Infectious Diseases in Clinical Practice: January 2010 - Volume 18 - Issue 1 - p 56-61
doi: 10.1097/IPC.0b013e3181a6539e
Case Reports

Rhinocerebral mucormycosis (RCM) is an increasingly common infection in immunocompromised subjects. We report a case of RCM in an immunosuppressed gentleman known to suffer from sigmoid colon adenocarcinoma stage D and presenting with diabetic ketoacidosis, complete ptosis, and orbital cellulitis. During his hospital stay, the patient developed cranial diabetes insipidus. In spite of extensive surgical debridement and high-dose liposomal amphotericin, the disease had a fatal outcome. This case emphasizes the need for increased awareness of mucormycosis as a potentially lethal fungal infection requiring a high index of suspicion in subjects at risk. The case also illustrates a rare complication of RCM, namely diabetes insipidus.

From the *Diabetes and Endocrine Centre, †Department of Infectious Diseases and ‡Ears, Nose and Throat Department, Mater Dei Hospital, Tal-Qroqq, Malta.

Reprints: Caroline Jane Magri, MD, MRCP, "Jesmel," Imdina Rd, Zebbug ZBG 05, Malta. E-mail:;

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.