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Massive Elevation of Procalcitonin in a Patient With Acquired Immunodeficiency Syndrome Due to Multicentric Castleman Disease

Bissinger, Alfred L. MD*; Schmidt, Susanne M. MD; Gregor, Michael PhD*; Berg, Christoph MD*; Raible, Armin MD*

Infectious Diseases in Clinical Practice: January 2010 - Volume 18 - Issue 1 - p 62-64
doi: 10.1097/IPC.0b013e3181ab2e64
Case Reports

A patient with human immunodeficiency virus having lymphadenoma, hepatosplenomegaly, fever, and weight loss was referred to the hospital. Because of a massive rise of procalcitonin, an extensive antibiotic therapy was initiated which, however, did not result in any clinical improvement. Tissue diagnosis revealed a multicentric Castleman disease. After consecutive chemotherapy, procalcitonin levels decreased by less than 3 log suggesting a causative role of multicentric Castleman disease.

From the *Departments of Internal Medicine I (Gastroenterology, Hepatology, Infectious Diseases) and †Internal Medicine II (Hematology, Oncology, Immunology), University Hospital Tübingen, Tübingen, Germany.

Reprints: Alfred Lennart Bissinger, MD, Department of Internal Medicine I, University Hospital Tübingen, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.