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Factors Associated With Increased Serum Alanine Aminotransferase Levels During the French Guiana Dengue Epidemic of 2005-2006

Dumortier, Caroline MD*; Djossou, Félix MD; Bernuau, Jacques MD; Basurko, Celia MD; Blanchon, Thierry MD§; Flahault, Antoine PhD§∥¶; Leport, Catherine PhD#

Infectious Diseases in Clinical Practice: January 2010 - Volume 18 - Issue 1 - p 41-45
doi: 10.1097/IPC.0b013e3181c75415
Original Articles

Mild elevation of aminotransferases is a common feature of dengue virus infection, and severe acute liver injury has been described. The aim of this retrospective study was to assess relationships between antipyretic drugs and chronic alcohol use and the increase in serum alanine aminotransferase (ALAT) level in patients hospitalized with dengue fever during the 2005-2006 dengue epidemics in French Guiana. In the 162 included patients in this study (99 adults [62%] and 63 children [38%]), 2 analysis were performed comparing (1) 64 adults (65%) with an ALAT value greater than twice the upper limit of the normal value and 35 controls (35%) and (2) 24 children (39%) with an ALAT value greater than twice the upper limit of the normal value and 38 controls (61%). The factors associated with ALAT elevation were: (1) acetaminophen exposure and length of intake in adults and (2) acetaminophen overdose during the hospitalization of children. Another analysis suggested a role for alcohol consumption. Acetaminophen and alcohol consumption should be searched and taken into account in dengue fever.

From the Departments of Infectious Diseases, *Xavier Bichat Hospital, Paris 7 University, Paris; †Andrée Rosemon Hospital, Cayenne, French Guyana; ‡Pôle des Maladies de l'Appareil Digestif, Department of Hepatology, Beaujon Hospital, 92118 Clichy; §Institut National de la Santé et de la Recherche Médicale (Inserm), WHO Collaborating Centre for Electronic Disease Surveillance, Université Pierre et Marie Curie, 27 rue Chaligny, F-75571 Paris Cedex 12; ∥French School of Public Health, Rennes and Paris; ¶Department of Public Health, AP-HP, Hôpital Tenon, Paris; and #Association for Research in Infectious Diseases (Association de recherche en pathologie infectieuse (ARPI)), Paris 7 University, Paris, France.

Reprints: Caroline Dumortier, MD, Secrétariat du Pr Catherine Leport Service de Maladies Infectieuses et Tropicales, Hôpital Xavier Bichat, 46 rue Henri Huchard, 75018 Paris, France. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.