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Osseointegration of Dental Implants in Organ Transplant Patients Undergoing Chronic Immunosuppressive Therapy

Radzewski, Rafał MD, DDS*; Osmola, Krzysztof MD, DDS, PhD

doi: 10.1097/ID.0000000000000916
Basic and Clinical Research

Introduction: The depressive impact of immunosuppressive medications used by patients after organ transplantations is commonly known and well proven. The aim of research is the assessment of functional and esthetic results of implantoprosthetic treatment in patients subject to immunosuppressive treatment after organ transplants.

Materials and Methods: The study encompassed a group of 21 patients in the course of maintenance immunosuppression after transplantation procedures, in whom altogether 24 implants were inserted. The control group comprised 15 people with 15 implants in place. The research protocol assumed replacing a single missing tooth with a titanium implant. After 4 months, a prosthetic reconstruction in the form of a single crown was performed. After 24 months, the preliminary assessment of treatment results was attempted. The measured parameter was crestal bone level (CBL). The mechanical assessment was performed by measuring the torque indispensable to locate the implant and by an objective measurement of implant stability.

Results: The basic measured parameter of CBL median in the experimental group and in the control group amounted to 0.325 mm (min 0–max 0.95) and 0.5 mm (min 0.15–max 1.8), respectively. The comparison of CBL medians revealed lack of significant differences between the experimental group and the control group (P = 0.089).

Conclusion: Patients with organ transplants can safely and effectively undergo dental implant treatment.

*PhD Student, Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Poznan, Poland.

Professor, Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Poznan, Poland.

Reprint requests and correspondence to: Rafał Radzewski, MD, DDS, Ethica Dental Clinic, Zbąszyńska 32/102, 60-397 Poznań, Poland, Phone: +48500085651, Fax: +48616711040, E-mail:

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