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Genetic Risk Factors for the Development of Periimplantitis

Fourmousis, Ioannis Dr med dent*; Vlachos, Manolis DDS, BSc, MSc

doi: 10.1097/ID.0000000000000874

Introduction: Periimplantitis etiology is multifactorial. The aim of this review is to identify the available data so far concerning the association between genetic polymorphisms and periimplantitis risk.

Materials and Methods: A literature search was performed in MEDLINE using the PubMed database of the US National Library of Medicine for articles published until March 2018. In addition, a manual search was performed. Our search and application of eligibility criteria provided 23 articles. Genes in these 23 studies could be divided into 3 overlapping categories: genes associated with (a) immune function, (b) bone growth, and (c) regulation of gene expression.

Discussion: The pathogenesis of periimplantitis is not currently well understood. There are some polymorphisms, for which different studies state consistent results. However, there are many polymorphisms with conflicting results, which could be attributed to differences in study design.

Conclusion: The identification of genetic biomarkers associated with periimplantitis risk could be valuable in daily clinical practice. However, no robust conclusions could be drawn from the current literature. The inequality of these studies' design necessitates the conduction of further studies using larger population samples and from different ethnic groups.

*Assistant Professor, Periodontology, University of Athens, Athens, Greece.

Dentist DDS, Private Practice, Athens, Greece.

Reprint requests and correspondence to: Ioannis Fourmousis, Dr med dent, Vasilissis Sofias Avenue 123, Athens 11521, Greece, Phone: +30 2103389980, Fax: 2103389981, E-mail:

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